Tylosin derivatives. V. Electrochemical opening of oxirane ring.
نویسندگان
چکیده
deepoxidation of 1 with dissolving metal (Zn). Reductive oxirane cleavage was accompanied by simultaneous allylic rearrangement giving 1 0, 1 3-dihydro1 3-hydroxy desmycosin (5). It is noteworthy that preparation of 1 consists of two steps2): oxidation of the 12,13-double bond with mchloroperbenzoic acid with simultaneous formation of TV-oxide, and reduction of the TV-oxide with Ph3P. Until now, electrochemical reduction of conjugated epoxy ketones has been described only in the case of steroid compounds3). In this paper we report electropp.1143 1145
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 52 12 شماره
صفحات -
تاریخ انتشار 1999